Dolo 650 : Uses, Benefits, Composition and Side Effects

Table of content

• What is the Dolo 650 composition?

• How does the Dolo 650 mg tablet work?

• 13 best uses of Dolo 650 tablet

• How to take a Dolo 650 MG tablet?

• Indications of Dolo 650

• Interactions of Dolo 650 tablet uses

• 8 most common side effects of Dolo 650 tablet

• Harmful effects due to overuse of Dolo 650

• Safety precautions or ontraindications of Dolo 650 tablet uses

• Alternate brands

• Take home points

• FAQ for Dolo 650 uses, benefits, composition, side effects

Introduction

The antipyretic activity (ability to reduce body temperature) of dolo 650 mg uses- to reduce body temperature. Analgesic activity (ability to relieve pain) of dolo 650 mg uses- in pain relief.

Dolo 650 mg tablet has become a popular go-to medicine since the occurrence of covid 19. The Dolo 650 mg tablet was manufactured by Micro labs Ltd of Bangalore. Despite the similarity with most other forms of paracetamol drug, dolo 650 tablet uses have become popular as it was trusted by many doctors and patients. 

What is the Dolo 650 composition?

• Dolo 650 mg tablet belongs to the class of aniline analgesics and not to the group of non-steroidal anti-inflammatory drugs (NSAIDs). 

• Dolo 650 composition includes 650 mg of paracetamol which is chemically known as Acetaminophen. 

• Acetaminophen, the Dolo 650 composition is the derivative of p-aminophenol and an active metabolite of phenacetin which is now withdrawn due to toxicity. 

Dosage form of Dolo 650 MG

• Dolo 650 MG exists in a solid form as paracetamol dolo 650 mg tablet.

• The chemical formula of the dolo 650 Mg tablet is C6H9NO2.

Other dosage forms

Dolo is also available in less dosage- 500 mg and as injection and syrup with lesser dosage to serve as per need.

Storage conditions of Dolo 650 mg tablet

• Before and after use of dolo 650 mg tablets preserve it at the temperature of 20oC to 25oC.

• Keep the dolo 650 mg tablet away from direct sunlight, air and heat to prevent damage. The occurrence of harmful effects is seen due to exposure of medicine.

• Dolo 650 mg tablets should be kept out of reach to children and animals. 

How does the Dolo 650 mg tablet work?

• The antipyretic action of the dolo 650 MG tablet is by inhibition of the production of prostaglandins that are responsible for enhanced body temperature.

• The analgesic action of the dolo 650 MG tablet is due to the selective inhibition of COX-3 (a splice variant of COX-1), in the central nervous system. Dolo 650 MG is a weak inhibitor of COX-1 and COX-2. 

13 best uses of Dolo 650 tablet

• The dolo 650 composition has the capacity to act as an antipyretic and analgesic drug.

• Dolo 650 tablet uses - for the treatment of headache, pain relief, fever, flu and the common cold.

The uses of dolo 650 mg tablet in various disease conditions is explained in brief below:

1. Uses of Dolo 650 for fever

• Dolo 650 composition includes paracetamol that helps to reduce our body temperature. Dolo 650 for fever is an oral form medication used during increased body temperatures. Dolo 650 mg tablet works by inhibiting the chemical release that causes fever.

• The dolo 650 tablet uses- to reduce weakness, treat loss of appetite, nausea, vomiting, and other symptoms associated with illness.

• The Use of dolo 650 mg for fever in children will help to relieve distress and loss of appetite. The body temperature is reduced by only 0.2oC in children after a dose completion of dolo 650 for fever when taken in low doses. 

• However, it is not advised to give more than the recommended use of dolo 650 for fever in children.

• Uses of dolo 650 for fever in adults - adults are allowed to take 4 to 6 doses without exceeding 4000mg.

2. Uses of Dolo 650 for cold

• Uses of dolo 650 for cold helps you relieve signs of a common cold like fatigue, pains, body temperature changes, loss of appetite. 

• The symptoms of the common cold include body temperature rise, body ache, lethargy, earache are treated when you use dolo 650 for cold.

• The common cold is a seasonal disease caused by cold temperature changes in the climate.

•  To treat the common cold, you can combine steam therapy and decongestants with dolo 650 tablet uses. 

3. Dolo 650 tablet uses for pain relief

• The dolo 650 composition exhibits an antipyretic effect for pain relief. Dolo 650 composition can be used to manage moderate to severe pains of muscle, head, tooth, arthritis.

• The use of dolo 650 for headaches associated with other diseases like fever, common cold, flu, sprains and dysmenorrhea can be effective.

4. Uses of Dolo 650 for Headache

• The Uses of dolo 650 for headaches helps in pain relief. Dolo 650 mg tablet is an over-the-counter drug easily available for all people.

• Dolo 650 for headaches like migraine - You can start the use of dolo 650 mg tablets from mild headaches to acute migraine for pain relief. 

• The Uses of dolo 650 for headaches in combination with caffeine and aspirin, has a strong effect on pain relief.

• The Uses of dolo 650 for headaches is more effective than the placebo study trial and dolo 650 mg tablet is considered as a remedy of first choice.

5. Dolo 650 tablet uses in muscle pain relief

• The uses of dolo 650 composition 

• for muscle pain caused by exercise, weight lifting, injury, illness helps in pain relief.

• Dolo 650 mg uses in acute low back pain are ineffective.

• Dolo 650 composition has no effect on chronic or radicular back pain.

6. Dolo 650 tablet uses in joint pain relief 

• Dolo 650 composition does not show any significant effect in the treatment of chronic osteoarthritis. 

• The dolo 650 tablet uses- to cure or aid pain relief in the less serious joint pains caused due to sudden twisting or standing up.

7. Dolo 650 uses in dental pain relief

In combination with codeine, the dolo 650 mg tablet when used for dental pain helps more efficiently than NSAIDs.

8. Dolo 650 uses in menstrual cramps

The Use of dolo 650 mg tablets helps to relieve menstrual pain in the stomach.

9. Dolo 650 uses in ear pain relief

Dolo 650 uses help to reduce earache in mild cases preventing ringing of the ears.

10. Dolo 650 uses in patent ductus arteriosus

Dolo 650 use in the closure of patent ductus arteriosus is more effective than ibuprofen and causes less gastrointestinal bleeding.

11. Dolo 650 uses in myalgia

Myalgia is symptomized with the presence of muscle pain. Dolo 650 mg use can give pain relief to muscles.

12. Dolo 650 uses in postpartum pain relief

Dolo 650 use in postpartum pain relief is less active than NSAIDs.

13. Dolo 650 uses in flu

• As discussed above the dolo 650 uses can help you reduce fever, common cold, pain and weakness associated with the flu. has

• Dolo 650 uses are vast as it serves both antipyretic and analgesic effects. Dolo 650 mg tablet is the best over-the-counter drug for all these symptoms reduction.

How to take a Dolo 650 MG tablet?

• Take the prescribed dose of dolo 650 MG tablet with a glass of water after food. Only swallow the dolo 650 MG tablet, do not chew, crush or break dolo 650 contents. 

• The usual dose of dolo is 500 mg, it also comes in different doses and dosage forms for efficient administration, depending on the patient’s condition and age.

• Try to take the dolo 50 mg tablet at the same time daily to maintain consistent improvement.

• Never stop the medication intake without consultation or prior to the course completion of the dolo 650 mg tablet.

Different doses of Dolo 650 composition based on the need

• For Adults: Paracetamol dolo 650 mg to 1000mg for every 4 hrs 

• For Pregnant women: Paracetamol dolo 650 mg to 1000 mg every 6 hrs (under supervision of a physician)

• For Kidney issues: Dolo 650 use is restricted to a specified dose with huge intervals

• For Liver failure: The dolo 650 use is contraindicated due to dolo 650 side effects

Indications of Dolo 650

• Dolo 650 mg tablets cannot be used during febrile seizures because the uses of dolo 650 do not prevent seizures.

• Avoid more than prescribed use of dolo 650 doses even if necessary or symptoms persist.

• Carry the dolo 650 mg tablet for any emergency use during pain or fever.

• Don’t mix a dolo 650 mg tablet with water or other drinks for easy administration. Dilution may decrease efficiency and increase bioavailability.

Interactions of Dolo 650 tablet uses

The dolo 650 mg tablet interacts with other drugs, food, or disease conditions after administration into the body. Some of the interactions of dolo 650 mg that have to be noted are as follows:

Paracetamol Dolo 650 food interactions

• Paracetamol dolo 650 interacts with alcohol and worsens liver issues.

• Consumption of paracetamol dolo 650 with tea, coffee, milk or any other beverages is prohibited.

Paracetamol Dolo 650 drug interactions

• The dolo 650 content is increased or the bioavailability of the dolo 650 Mg tablet is enhanced by the interaction of prokinetic agents like metoclopramide (a drug that prevents nausea and vomiting).

• The availability of dolo 650 content is decreased by the drugs like propantheline and morphine leading to a decrease of dolo 650 uses in the body.

• Ranitidine, cisapride, and nizatidine all decrease the dolo 650 content availability in the body.

• The paracetamol dolo 650 increases ethinylestradiol plasma concentrations and warfarin accessibility during the therapy.

Paracetamol Dolo 650 disease interactions

• The dolo 650 Mg tablet interacts with the liver functions of chronic alcohol patients leading to severe liver damage. 

• The paracetamol dolo 650 uses interrupt lung function when taken during asthma.

• Dolo 650 uses-cause adverse effects by intrusion if given during kidney, pancreatitis, heart issues, and IBD (Inflammatory bowel disease).

Paracetamol dolo 650 interactions in lab tests

• The dolo 650 composition gives a positive result in the 5-HIAA (5-Hydroxyindoleacetic acid) urine test. 

• So, you have to inform your doctor about the prescribed medicines like dolo 650 mg tablet before you get tested.

8 most common side effects of Dolo 650 tablet

The dolo 650 side effects are mostly not fatal and will fade away after the initial adjusting phase where your body tries to withstand the changes caused by dolo 650 tablet uses. But when taken during some disease conditions the dolo 650 tablet uses will lead to death causing serious dolo 650 side effects. 

Some common side effects or harmful effects are described in this section. If any of these symptoms persist, please consult a doctor.

1. Dolo 650 side effects on Skin

Paracetamol dolo 650 is not suitable for all people. So, some individuals may feel skin rashes (Erythema), redness, itching, swelling of face, lips, tongue, or maybe fatal skin reactions (Toxic epidermal necrolysis).

All these dolo 650 side effects can be seen within the first administration of the dolo tablet uses or after several dolo 650 tablet uses of the medicine. The adverse effects are due to intolerance to dolo 650 uses.

2. Dolo 650 side effects on Liver

Dolo 650 tablet use can lead to liver injury in chronic alcohol consumption people. The dolo 650 tablet uses- will cause adverse effects like loss of appetite, nausea, pain, fatigue, yellowing of eyes, urine and stool.

You may feel ill at the time of dolo 650 use. 

3. Dolo 650 side effects on Asthma

The dolo 650 uses -interacts with the lungs, causing difficulty in breathing, short breath, spasm of the larynx (causes difficulty to speak or breath). 

The use of dolo 650 mg tablets decreases lung function leading to harmful effects.

4. Dolo 650 side effects on the Central nervous system

The Uses of dolo 650 mg tablet interrupts the normal functioning of the nervous system

5. Dolo 650 side effects on Heart rate

Dolo 650 use causes disturb the normal functioning of the heart by amplified heartbeat and other harmful effects in heart patients.

6. Dolo 650 side effects on Blood and blood pressure

As the use of dolo 650 mg tablets interferes with the action of COX it leads to difficulty in the formation of blood clots and causes extreme bleeding. 

The dolo 650 use decreases the blood pressure (Hypotension), decreases the platelets count (Thrombocytopenia) and white blood cells (Agranulocytosis).

7. Dolo 650 side effects on Gastrointestinal effects

Common side effects like diarrhea and constipation are observed with the use of dolo 650 mg tablets. Dolo 650 use can also lead to stomach ulcers and gastrointestinal bleeding on long-term use.

8. Dolo 650 side effects on Kidney

• Abnormal kidney function is the common side effects of dolo 650 use. Kidney impairment and kidney cancer are the harmful effects caused due to the long-term use of dolo 650 content.

• Long-term use of dolo 650 mg tablets causes bloody and cloudy urine which is a severely harmful effect. 

• If you experience any of the common side effects or one of the dolo 650 side effects immediately ask a physician’s advice for long-term use.

Other adverse effects

Some adverse effects caused by the uses of dolo 650 content are as follows:

• Nausea, vomiting 

• Stomach upset, pain

• Hypersensitivity reactions like allergies

• Malaise (feeling of illness, weakness, mild pains)

• Lack of interest 

Harmful effects due to overuse of Dolo 650

What is Overdosage?

• When you take the prescribed medicines more than the necessary dosage either by accident or long-term use or intentionally is called overdosage.

• Overdose of dolo 650 tablet uses will cause many harmful effects to adults and children (more than the maximum daily dose).

What are the harmful effects caused by the overdose of Dolo 650 mg use?

Extreme dolo 650 tablet uses may lead to:

• Liver damage (Hepatotoxicity)

• Kidney failure 

• Paracetamol dolo 650 poisoning

• Sleeplessness

• Hospitalization

• Death

What causes the toxicity of Dolo 650 use?

• In most cases, the toxicity can be due to the long-term use of the dolo 650 mg tablet. The quinone metabolite formed during the metabolism of dolo 650 tablet uses, is the cause of the poisoning effect.

• In some cases, the harmful effects are due to the lower glucuronide conjugation (a process required to break the harmful quinone) ability of an individual. This capacity is lower in children and diseased people compared to adults.

What is the treatment for overdose of Dolo 650 tablet uses?

The administration of N-acetylcysteine (I.V) or Metathione (Oral). 

These compounds help in the glutathione conjugation relieving the toxins in the kidney and liver thus preventing paracetamol toxicity.

Safety precautions or contraindications of Dolo 650 tablet uses

Avoid alcohol  

To avoid the adverse effects of the dolo 650 use do not take alcohol. The dolo 650 use can also be fatal when taken along with alcohol.

Liver impairment

Patients with liver damage should inform the doctor about the condition and the prescribed medicines to prevent further occurrence of dolo 650 side effects caused by dolo 650 use.

Pregnant Women

Pregnant women should take a dolo 650 mg tablet under the supervision of a physician. 

During Breastfeeding/lactation

The use of a dolo 650 mg tablet does not affect the baby if you are breastfeeding. Dolo 650 composition does not pass-through breastmilk so it is ok to use dolo 650 mg on the advice of a physician.

Kidney failure

All patients with kidney impairment should give detailed information on the prescribed medicines to the doctor to avoid the damage caused by the dolo 650 use.

Hypersensitivity

Do not take a dolo 650 mg tablet when you have any allergies to paracetamol or drugs in combination with it.

Check with the doctor if you experience any of the above adverse effects or side effects for more than a day.

Alternate brands

• Calpol 650

• Crocin 650

• Algina 650

• Pacimol 650

• Paracip 650

• Dolopar 650

• Febrinil 650

• Pacimol 650 

• Parafizz 650

• Fepanil 650

• Xykaa rapid 650

• P 650

• Sumo L 650

Take home points

• Paracetamol dolo 650 mg helps to reduce body temperature, common cold, and aids in pain relief.

• Avoid taking alcohol along with a dolo 650mg tablet.

• Dolo 650 mg tablet does not affect pregnant and breastfeeding women.

• The higher doses of dolo 650 use cause toxicity.

• Inform the doctor about your medical conditions like liver or kidney impairment before the prescription.

References

• NCBI

• NCBI

• NCBI

• NCBI